Cramer-Rao analysis of steady-state and time-domain fluorescence diffuse optical imaging
نویسندگان
چکیده
Using a Cramer-Rao analysis, we study the theoretical performances of a time and spatially resolved fDOT imaging system for jointly estimating the position and the concentration of a point-wide fluorescent volume in a diffusive sample. We show that the fluorescence lifetime is a critical parameter for the precision of the technique. A time resolved fDOT system that does not use spatial information is also considered. In certain cases, a simple steady-state configuration may be as efficient as this time resolved fDOT system.
منابع مشابه
Early-photon fluorescence tomography: spatial resolution improvements and noise stability considerations.
In vivo tissue imaging using near-infrared light suffers from low spatial resolution and poor contrast recovery because of highly scattered photon transport. For diffuse optical tomography (DOT) and fluorescence molecular tomography (FMT), the resolution is limited to about 5-10% of the diameter of the tissue being imaged, which puts it in the range of performance seen in nuclear medicine. This...
متن کاملTraining sequence based frequency-domain channel estimation for indoor diffuse wireless optical communications
Channel estimation is a key technology for wireless optical communication (WOC) systems. Based on the training sequence (TS), this article develops three frequency domain (FD) channel estimation approaches for diffuse wireless optical channels. Considering the propagation property of light and the characteristics of optical modulation, this article establishes a link model for the indoor WOC sy...
متن کاملResolution below the point spread function for diffuse optical imaging using fluorescence lifetime multiplexing.
We show that asymptotic lifetime-based fluorescence tomography can localize multiple-lifetime targets separated well below the diffuse point spread function of a turbid medium. This is made possible due to a complete diagonalization of the time domain forward problem in the asymptotic limit. We also show that continuous wave or direct time gate approaches to fluorescence tomography are unable t...
متن کاملImproved Cramer-Rao Inequality for Randomly Censored Data
As an application of the improved Cauchy-Schwartz inequality due to Walker (Statist. Probab. Lett. (2017) 122:86-90), we obtain an improved version of the Cramer-Rao inequality for randomly censored data derived by Abdushukurov and Kim (J. Soviet. Math. (1987) pp. 2171-2185). We derive a lower bound of Bhattacharya type for the mean square error of a parametric function based on randomly censor...
متن کاملTime-to-Digital Converter card for multichannel time-resolved Single-Photon Counting applications
We present a high performance Time-to-Digital Converter (TDC) card that provides 10 ps timing resolution and 20 ps (rms) timing precision with a programmable full-scale-range from 160 ns to 10 μs. Differential Non-Linearity (DNL) is better than 1.3% LSB (rms) and Integral Non-Linearity (INL) is 5 ps rms. Thanks to the low power consumption (400 mW) and the compact size (78 mm x 28 mm x 10 mm), ...
متن کامل